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639863-77-7

639863-77-7 structure
639863-77-7 structure
  • Name: N-Desmethyl Pimavanserin
  • Chemical Name: N-Desmethyl Pimavanserin
  • CAS Number: 639863-77-7
  • Molecular Formula: C24H32FN3O2
  • Molecular Weight: 413.53
  • Create Date: 2020-01-23 13:15:51
  • Modify Date: 2024-01-09 20:29:55
  • N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
Name N-Desmethyl Pimavanserin
Description N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
In Vitro The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.
References

[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.
Molecular Formula C24H32FN3O2
Molecular Weight 413.53

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title: CAS No. 639863-77-7 | Chemsrc address: https://m.chemsrc.com/en/baike/1562041.html

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