N-Desmethyl Pimavanserin

Modify Date: 2025-09-10 10:27:41

N-Desmethyl Pimavanserin Structure
N-Desmethyl Pimavanserin structure
 Common Name N-Desmethyl Pimavanserin
CAS Number 639863-77-7 Molecular Weight 413.53
Density N/A Boiling Point N/A
Molecular Formula C24H32FN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-Desmethyl Pimavanserin


N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

 Names

Name N-Desmethyl Pimavanserin

 N-Desmethyl Pimavanserin Biological Activity

Description N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
In Vitro The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.
References

[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

 Chemical & Physical Properties

Molecular Formula C24H32FN3O2
Molecular Weight 413.53
InChIKey CJAUQHPXNICIJI-UHFFFAOYSA-N
SMILES CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1
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