2185795-53-1

2185795-53-1 structure

Name: PROTAC BRD4 Degrader-2
Chemical Name: PROTAC BRD4 Degrader-2
CAS Number: 2185795-53-1
Molecular Formula: C₄₀H₃₉N₉O₇
Molecular Weight: 757.79
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2020-01-23 18:42:51
Modify Date: 2024-01-02 17:37:27
PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1[1].

Name	PROTAC BRD4 Degrader-2

Description	PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Cereblon BRD4 BD1:14.2 nM (IC50)
In Vitro	PROTAC BRD4 Degrader-2 (Compound 17) inhibits the growth of THP-1 cell line with an IC50 of 1.83±0.016 μM[1]. Cell Proliferation Assay[1] Cell Line: Human monocyte lymphoma cell line THP-1 Concentration: 72 hours Incubation Time: 0.81-3.26 μM Result: Showd high anti-proliferative potency.
References	[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.