666174-75-0

666174-75-0 structure

Name: Guttiferone G
Chemical Name: Guttiferone G
CAS Number: 666174-75-0
Molecular Formula: C₄₃H₅₈O₆
Molecular Weight: 670.92
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2020-02-11 18:17:26
Modify Date: 2022-05-09 09:02:23
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla[1][2].

Name	Guttiferone G

Description	Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	IC50: 9 and 22 μM (SIRT1/2)[1]
References	[1]. Williams RB, et al. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest. Planta Med. 2003 Sep;69(9):864-6. [2]. Gey C, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46(27):5219-22.