2365497-07-8
2365497-07-8 structure
- Name: ALK/ROS1-IN-1
- Chemical Name: ALK/ROS1-IN-1
- CAS Number: 2365497-07-8
- Molecular Formula: C30H35F3N6O3
- Molecular Weight: 584.63
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
- Create Date: 2020-04-04 14:08:01
- Modify Date: 2024-01-11 18:31:43
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ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively.
| Name | ALK/ROS1-IN-1 |
|---|
| Description | ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively. |
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| Related Catalog | |
| Target |
IC50: 0.174 μM (ALK), 0.530 μM (ROS1)[1] |
| In Vitro | ALK/ROS1-IN-1 displays potent anti-proliferative activity against ALK-addicted H3122 and ROS1-addicted HCC78 cell lines (IC50= 6.27 μM and 10.71 μM, respectively)[1]. ALK/ROS1-IN-1 shows impressive enzyme activity against clinically Crizotinib-resistant ALKL1196M with an IC50 value of 41.3 nM[1]. ALK/ROS1-IN-1 shows potent inhibitory activity in Ba/F3 cell line expressing ROS1 mutants, with IC50s of 137.7, 104.7 nM and 233.9 for wide-type, G2032R mutant and L2026M mutant, respectively[1]. ALK/ROS1-IN-1 has no significant effect on inducing apoptosis of HCC78 cell line[1]. |
| References |
| Molecular Formula | C30H35F3N6O3 |
|---|---|
| Molecular Weight | 584.63 |