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175885-18-4

175885-18-4 structure
175885-18-4 structure
  • Name: Biotin-PEG2-NH-Boc
  • Chemical Name: Biotin-PEG2-NH-Boc
  • CAS Number: 175885-18-4
  • Molecular Formula: C21H38N4O6S
  • Molecular Weight: 474.61
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2020-04-07 16:42:58
  • Modify Date: 2024-01-08 11:56:15
  • Biotin-PEG2-NH-Boc is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Biotin-PEG2-NH-Boc
Synonyms MFCD30527392
Description Biotin-PEG2-NH-Boc is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Molecular Formula C21H38N4O6S
Molecular Weight 474.61
Hazard Codes Xi