1800296-63-2
1800296-63-2 structure
- Name: DHODH-IN-1
- Chemical Name: DHODH-IN-1
- CAS Number: 1800296-63-2
- Molecular Formula: C21H20F3N3O2
- Molecular Weight: 403.40
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-04-09 17:18:53
- Modify Date: 2024-01-29 07:26:40
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DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1].
| Name | DHODH-IN-1 |
|---|
| Description | DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 25 nM (DHODH)[1] |
| In Vitro | DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM)[1]. DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells[1]. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules[1]. Cell Proliferation Assay[1] Cell Line: Jurkat cells Concentration: 0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 μM Incubation Time: 72 hours Result: Strongly inhibited Jurkat cells proliferation (IC50=0.02 μM). |
| In Vivo | DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1]. |
| References |
| Molecular Formula | C21H20F3N3O2 |
|---|---|
| Molecular Weight | 403.40 |