1416990-08-3

1416990-08-3 structure

Name: Lenalidomide-OH
Chemical Name: Lenalidomide-OH
CAS Number: 1416990-08-3
Molecular Formula: C₁₃H₁₂N₂O₄
Molecular Weight: 260.25
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2020-04-05 14:36:08
Modify Date: 2024-01-06 15:28:21
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].

Name	Lenalidomide-OH
Synonyms	MFCD31794971

Description	Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
References	[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

Molecular Formula	C₁₃H₁₂N₂O₄
Molecular Weight	260.25

Hazard Codes	Xi