204992-09-6
204992-09-6 structure
- Name: Nemifitide diTFA
- Chemical Name: Nemifitide diTFA
- CAS Number: 204992-09-6
- Molecular Formula: C37H45F7N10O10
- Molecular Weight: 922.80
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-04-05 19:37:17
- Modify Date: 2024-01-07 11:48:41
-
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].
| Name | Nemifitide diTFA |
|---|
| Description | Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3]. |
|---|---|
| Related Catalog | |
| In Vitro | Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3]. |
| In Vivo | Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2]. Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2]. Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2] Dosage: 0.3 mg/kg Administration: IP; daily; for 14 days Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |
| References |
| Molecular Formula | C37H45F7N10O10 |
|---|---|
| Molecular Weight | 922.80 |