2242855-68-9

2242855-68-9 structure

Name: NR1H4 activator 1
Chemical Name: NR1H4 activator 1
CAS Number: 2242855-68-9
Molecular Formula: C₃₄H₅₃NO₇S
Molecular Weight: 619.85
Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
Create Date: 2020-04-07 20:03:50
Modify Date: 2025-08-25 00:22:43
NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].

Name	NR1H4 activator 1

Description	NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Inflammation/Immunology
Target	EC50: 1 nM (Famesoid X Receptor)[1]
In Vitro	NR1H4 activator 1 exhibits a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. This assay is aim to determinate the ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR[1].
References	[1]. Guoqiang Wang, et al. Bile acid derivatives as fxr agonists and methods of use thereof. Patent WO2018152171A1.

Molecular Formula	C₃₄H₅₃NO₇S
Molecular Weight	619.85