1623002-61-8

1623002-61-8 structure

Name: NTRC 824
Chemical Name: NTRC-824
CAS Number: 1623002-61-8
Molecular Formula: C₂₅H₂₆F₃N₃O₆S
Molecular Weight: 553.55
Catalog: Signaling Pathways GPCR/G Protein Neurotensin Receptor
Create Date: 2020-04-06 19:18:14
Modify Date: 2024-01-08 12:31:05
NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1].

Name	NTRC-824

Description	NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
Target	IC50: 38 nM (Nurotensin receptor type 2)[1] Ki: 202 nM (Nurotensin receptor type 2)[1]
In Vitro	Testing of NTRC-824 (Compound 5) at the NTS1 receptor shows no binding activity in the NTS1 assay up to 30 μM, making NTRC-824 (Compound 5) selective for NTS2 in both the binding and functional assays. NTRC-824 (Compound 5) is the first nonpeptide compound that behaves like, and is more active than, the endogenous ligand[1].
References	[1]. Thomas JB, et al. Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J Med Chem. 2014 Sep 11;57(17):7472-7.

Molecular Formula	C₂₅H₂₆F₃N₃O₆S
Molecular Weight	553.55