NTRC 824

Modify Date: 2024-01-08 12:31:05

NTRC 824 Structure
NTRC 824 structure
 Common Name NTRC 824
CAS Number 1623002-61-8 Molecular Weight 553.55
Density N/A Boiling Point N/A
Molecular Formula C25H26F3N3O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NTRC 824


NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1].

 Names

Name NTRC-824

 NTRC 824 Biological Activity

Description NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1].
Related Catalog
Target

IC50: 38 nM (Nurotensin receptor type 2)[1] Ki: 202 nM (Nurotensin receptor type 2)[1]

In Vitro Testing of NTRC-824 (Compound 5) at the NTS1 receptor shows no binding activity in the NTS1 assay up to 30 μM, making NTRC-824 (Compound 5) selective for NTS2 in both the binding and functional assays. NTRC-824 (Compound 5) is the first nonpeptide compound that behaves like, and is more active than, the endogenous ligand[1].
References

[1]. Thomas JB, et al. Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J Med Chem. 2014 Sep 11;57(17):7472-7.

 Chemical & Physical Properties

Molecular Formula C25H26F3N3O6S
Molecular Weight 553.55
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Chemsrc provides NTRC 824(CAS#:1623002-61-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of NTRC 824 are included as well.>> amp version: NTRC 824

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