183945-55-3

183945-55-3 structure

Name: PfDHODH-IN-1
Chemical Name: PfDHODH-IN-1
CAS Number: 183945-55-3
Molecular Formula: C₁₄H₁₁F₃N₂O₂
Molecular Weight: 296.24
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2020-04-07 16:04:48
Modify Date: 2025-08-26 19:12:00
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity[1][2].

Name	PfDHODH-IN-1

Description	PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
References	[1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. [2]. Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24.

Molecular Formula	C₁₄H₁₁F₃N₂O₂
Molecular Weight	296.24