1928724-23-5
1928724-23-5 structure
- Name: SK33
- Chemical Name: SK33
- CAS Number: 1928724-23-5
- Molecular Formula: C20H13F9N2O3
- Molecular Weight: 500.31
- Catalog: Signaling Pathways Others Androgen Receptor
- Create Date: 2020-04-14 22:46:00
- Modify Date: 2024-01-15 23:39:32
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SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].
| Name | SK33 |
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| Description | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. |
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| Related Catalog | |
| In Vitro | In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1]. Cell Viability Assay[1] Cell Line: LNCaP/BicR cells Concentration: 0.1-100 μM Incubation Time: 96 hours Result: Results in a dose-dependent response and an inhibition of cell growth. |
| In Vivo | SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1]. Animal Model: ARE-Luc mice[1] Dosage: 50 mg/kg Administration: Subcutaneously; 24 hours Result: Inhibited AR transcriptional activity. |
| References |
| Molecular Formula | C20H13F9N2O3 |
|---|---|
| Molecular Weight | 500.31 |