7414-56-4
7414-56-4 structure
- Name: ADENYLYLMETHYLENEDIPHOSPHONATE SODIUM SALT
- Chemical Name: AMP-PCP disodium
- CAS Number: 7414-56-4
- Molecular Formula: C11H16N5Na2O12P3
- Molecular Weight: 549.17
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2020-06-01 12:36:34
- Modify Date: 2024-01-03 11:44:35
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AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1].
| Name | AMP-PCP disodium |
|---|
| Description | AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1]. |
|---|---|
| Related Catalog | |
| Target |
HSP90:3.8 μM (Kd) |
| In Vitro | AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1]. |
| References |
| Molecular Formula | C11H16N5Na2O12P3 |
|---|---|
| Molecular Weight | 549.17 |
| Storage condition | -20°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H311-H315-H319-H331-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | 23/24/25-36/37/38 |
| Safety Phrases | 22-26-36-45 |
| RIDADR | NONH for all modes of transport |