1426174-41-5

1426174-41-5 structure
1426174-41-5 structure
  • Name: Ezetimibe phenoxy glucuronide-D4
  • Chemical Name: Ezetimibe phenoxy glucuronide-D4
  • CAS Number: 1426174-41-5
  • Molecular Formula: C30H25D4F2NO9
  • Molecular Weight: 589.57
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2020-06-01 14:43:29
  • Modify Date: 2024-01-03 19:26:08
  • Ezetimibe phenoxy glucuronide-D4 (Ezetimibe glucuronide-D4) is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

Name Ezetimibe phenoxy glucuronide-D4
Description Ezetimibe phenoxy glucuronide-D4 (Ezetimibe glucuronide-D4) is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
Related Catalog
In Vivo After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].
References

[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11.

[2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

Molecular Formula C30H25D4F2NO9
Molecular Weight 589.57