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2194903-42-7

2194903-42-7 structure
2194903-42-7 structure
  • Name: H3B-120
  • Chemical Name: H3B-120
  • CAS Number: 2194903-42-7
  • Molecular Formula: C19H24N4O2S
  • Molecular Weight: 372.48
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
  • Create Date: 2020-06-01 23:16:56
  • Modify Date: 2024-01-08 18:31:06
  • H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].

Name H3B-120
Description H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].
Related Catalog
Target

IC50: 1.5 μM (CPS1)[1] Ki: 1.4 μM (CPS1)[1]

In Vitro H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase)[1]. H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains[1]. H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays[1]. The half-life of H3B-120 is only 40 min[1].
References

[1]. Yao S, et al. Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol. 2020 Mar 19;27(3):259-268.

Molecular Formula C19H24N4O2S
Molecular Weight 372.48
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