2194903-42-7
2194903-42-7 structure
- Name: H3B-120
- Chemical Name: H3B-120
- CAS Number: 2194903-42-7
- Molecular Formula: C19H24N4O2S
- Molecular Weight: 372.48
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2020-06-01 23:16:56
- Modify Date: 2024-01-08 18:31:06
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H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].
| Name | H3B-120 |
|---|
| Description | H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
IC50: 1.5 μM (CPS1)[1] Ki: 1.4 μM (CPS1)[1] |
| In Vitro | H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase)[1]. H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains[1]. H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays[1]. The half-life of H3B-120 is only 40 min[1]. |
| References |
| Molecular Formula | C19H24N4O2S |
|---|---|
| Molecular Weight | 372.48 |