H3B-120

Modify Date: 2024-01-08 18:31:06

H3B-120 structure	Common Name	H3B-120
	CAS Number	2194903-42-7	Molecular Weight	372.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₄N₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of H3B-120

H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].

Name	H3B-120

Description	H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 1.5 μM (CPS1)[1] Ki: 1.4 μM (CPS1)[1]
In Vitro	H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase)[1]. H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains[1]. H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays[1]. The half-life of H3B-120 is only 40 min[1].
References	[1]. Yao S, et al. Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol. 2020 Mar 19;27(3):259-268.

Molecular Formula	C₁₉H₂₄N₄O₂S
Molecular Weight	372.48

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: H3B-120
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: H3B-120
Price: $650.0/100mg $1100.0/250mg $2200.0/1g ￥220.0/10ml
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥3000/5 mg

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H3B-120

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