313964-19-1

313964-19-1 structure

Name: HIF-2α-IN-3
Chemical Name: HIF-2α-IN-3
CAS Number: 313964-19-1
Molecular Formula: C₁₂H₆ClN₅O₅
Molecular Weight: 335.66
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2020-06-01 16:53:30
Modify Date: 2024-04-05 18:24:27
HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].

Name	HIF-2α-IN-3

Description	HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 0.4 µM (HIF-2α)[1] KD: 1.1 µM (HIF-2α)[1]
In Vitro	HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].
References	[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.