HIF-2α-IN-3

Modify Date: 2024-04-05 18:24:27

HIF-2α-IN-3 structure	Common Name	HIF-2α-IN-3
	CAS Number	313964-19-1	Molecular Weight	335.66
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₆ClN₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIF-2α-IN-3

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].

Name	HIF-2α-IN-3

Description	HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 0.4 µM (HIF-2α)[1] KD: 1.1 µM (HIF-2α)[1]
In Vitro	HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].
References	[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.

Molecular Formula	C₁₂H₆ClN₅O₅
Molecular Weight	335.66
Storage condition	2-8°C