2379279-96-4
2379279-96-4 structure
- Name: HSD1590
- Chemical Name: HSD1590
- CAS Number: 2379279-96-4
- Molecular Formula: C20H18BN3O3
- Molecular Weight: 359.19
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
- Create Date: 2020-06-01 12:26:35
- Modify Date: 2024-01-30 21:53:39
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HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity[1].
| Name | HSD1590 |
|---|
| Description | HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity[1]. |
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| Related Catalog | |
| Target |
ROCK1:1.22 nM (IC50) ROCK2:0.51 nM (IC50) |
| In Vitro | HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration[1]. HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration[1]. Cell Viability Assay[1] Cell Line: MDA-MB-23 cells Concentration: 0.5-10 µM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h. |
| References |
| Molecular Formula | C20H18BN3O3 |
|---|---|
| Molecular Weight | 359.19 |