2321366-46-3

2321366-46-3 structure

Name: Nω-Propyl-L-arginine hydrochloride
Chemical Name: Nω-Propyl-L-arginine hydrochloride
CAS Number: 2321366-46-3
Molecular Formula: C₉H₂₁ClN₄O₂
Molecular Weight: 252.74
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2020-06-01 10:01:11
Modify Date: 2024-06-19 17:10:46
Nω-Propyl-L-arginine hydrochloride (N-omega-Propyl-L-arginine hydrochloride) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].

Name	Nω-Propyl-L-arginine hydrochloride

Description	Nω-Propyl-L-arginine hydrochloride (N-omega-Propyl-L-arginine hydrochloride) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
In Vivo	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) hydrochloride blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2]. Animal Model: Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2] Dosage: 20 mg/kg Administration: I.p. Result: Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
References	[1]. Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. [2]. Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7.

Molecular Formula	C₉H₂₁ClN₄O₂
Molecular Weight	252.74