1783978-03-9

1783978-03-9 structure

Name: PNU 177864 hydrochloride
Chemical Name: PNU-177864 hydrochloride
CAS Number: 1783978-03-9
Molecular Formula: C₁₈H₂₂ClF₃N₂O₃S
Molecular Weight: 438.89
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2020-06-01 12:26:13
Modify Date: 2024-01-08 23:01:44
PNU-177864 hydrochloride is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic drug (CAD) and induces phospholipidosis in vivo. PNU-177864 hydrochloride antischizophrenic activity[1][2].

Name	PNU-177864 hydrochloride

Description	PNU-177864 hydrochloride is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic drug (CAD) and induces phospholipidosis in vivo. PNU-177864 hydrochloride antischizophrenic activity[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D3 Receptor
In Vivo	PNU-177864 (12.5-200 mg/kg; oral gavage; daily; for 2-4 weeks; Sprague-Dawley rats) treatment induces phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles[1]. Animal Model: Male and female Sprague-Dawley rats (8-9-week-old)[1] Dosage: 12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks) Administration: Oral gavage; daily; for 2-4 weeks Result: Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
References	[1]. Rudmann DG, et al. Epididymal and systemic phospholipidosis in rats and dogs treated with the dopamine D3 selective antagonist PNU-177864. Toxicol Pathol. 2004 May-Jun;32(3):326-32. [2]. Vonderfecht SL, et al. Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol Pathol. 2004 May-Jun;32(3):318-25.

Molecular Formula	C₁₈H₂₂ClF₃N₂O₃S
Molecular Weight	438.89