2220175-42-6

2220175-42-6 structure

Name: Polymyxin B nonapeptide TFA
Chemical Name: Polymyxin B nonapeptide TFA
CAS Number: 2220175-42-6
Molecular Formula: C₄₃H₇₄N₁₄O_11.5C₂HF₃O₂
Molecular Weight: 1533.25
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-06-01 16:40:40
Modify Date: 2024-01-16 17:35:40
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].

Name	Polymyxin B nonapeptide TFA

Description	Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1].
References	[1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92. [2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.

Molecular Formula	C₄₃H₇₄N₁₄O_11.5C₂HF₃O₂
Molecular Weight	1533.25

Hazard Codes	Xi