Polymyxin B nonapeptide TFA

Modify Date: 2024-01-16 17:35:40

Polymyxin B nonapeptide TFA structure	Common Name	Polymyxin B nonapeptide TFA
	CAS Number	2220175-42-6	Molecular Weight	1533.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₃H₇₄N₁₄O_11.5C₂HF₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Polymyxin B nonapeptide TFA

Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].

Name	Polymyxin B nonapeptide TFA

Description	Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1].
References	[1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92. [2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.

Molecular Formula	C₄₃H₇₄N₁₄O_11.5C₂HF₃O₂
Molecular Weight	1533.25

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: Polymyxin B nonapeptide TFA
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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