2376139-49-8

2376139-49-8 structure

Name: (S,R,S)-AHPC-C8-NH2 (hydrochloride)
Chemical Name: (S,R,S)-AHPC-C8-NH2 hydrochloride
CAS Number: 2376139-49-8
Molecular Formula: C₃₁H₄₈ClN₅O₄S
Molecular Weight: 622.26
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 11:54:34
Modify Date: 2024-01-05 12:30:24
(S,R,S)-AHPC-C7-NH2 hydrochloride (VH032-C7-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C7-NH2 hydrochloride is XF038-164A, example 8, extracted from patent WO2019173516A1[1].

Name	(S,R,S)-AHPC-C8-NH2 hydrochloride

Description	(S,R,S)-AHPC-C7-NH2 hydrochloride (VH032-C7-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C7-NH2 hydrochloride is XF038-164A, example 8, extracted from patent WO2019173516A1[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.

Molecular Formula	C₃₁H₄₈ClN₅O₄S
Molecular Weight	622.26

Hazard Codes	Xi