2097509-40-3

2097509-40-3 structure

Name: Thalidomide-NH-PEG2-C2-NH-Boc
Chemical Name: Thalidomide-NH-PEG2-C2-NH-Boc
CAS Number: 2097509-40-3
Molecular Formula: C₂₄H₃₂N₄O₈
Molecular Weight: 504.53
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 11:57:29
Modify Date: 2024-04-05 23:23:46
Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].

Name	Thalidomide-NH-PEG2-C2-NH-Boc

Description	Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
In Vitro	dBRD9 (0-1 μM) exerts a potent anti-proliferative effect, exceeding non-degrading probe potencies in excesses of 10 to 100 fold[1].
References	[1]. David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743.

Molecular Formula	C₂₄H₃₂N₄O₈
Molecular Weight	504.53

Hazard Codes	Xi