1309925-39-0

1309925-39-0 structure

Name: Tubulin inhibitor 8
Chemical Name: Tubulin inhibitor 8
CAS Number: 1309925-39-0
Molecular Formula: C₂₁H₁₄N₂O₃
Molecular Weight: 342.35
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2020-06-01 13:05:14
Modify Date: 2024-01-22 16:24:00
Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].

Name	Tubulin inhibitor 8

Description	Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 0.73 μM (tubulin polymerization)[1]
In Vitro	Tubulin inhibitor 8 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1]. Tubulin inhibitor 8 shows excellent antiproliferative potencies with IC50s of 15, 6, 8, 2, 8, 6, and 9 nM for NCIH460, SKOV3, BT549, 451LU, SW480, COLO-205, and DLD-1 tumor cell lines, recpectively[1].
References	[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

Molecular Formula	C₂₁H₁₄N₂O₃
Molecular Weight	342.35

Hazard Codes	Xi