1268955-50-5
1268955-50-5 structure
- Name: TXNIP-IN-1
- Chemical Name: TXNIP-IN-1
- CAS Number: 1268955-50-5
- Molecular Formula: C12H12N2O4
- Molecular Weight: 248.23
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-06-01 18:45:15
- Modify Date: 2024-01-14 12:21:36
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TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease[1].
| Name | TXNIP-IN-1 |
|---|
| Description | TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease[1]. |
|---|---|
| Related Catalog | |
| Target |
TXNIP-TRX complex[1] |
| In Vitro | TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation[1]. TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF in monocytes[1]. TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression in THP1 cells[1]. TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages[1]. TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels in MIN6 cells[1]. TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells[1]. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose[1]. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets[1]. |
| References |
[1]. Rama Natarajan, et al. Txnip-trx complex inhibitors and methods of using the same. US20200085800A1. |
| Molecular Formula | C12H12N2O4 |
|---|---|
| Molecular Weight | 248.23 |