1269190-98-8
1269190-98-8 structure
- Name: yGsy2p-IN-H23
- Chemical Name: yGsy2p-IN-H23
- CAS Number: 1269190-98-8
- Molecular Formula: C23H27N3O2
- Molecular Weight: 377.48
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-06-01 12:21:50
- Modify Date: 2025-08-27 08:13:42
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yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for glycogen storage diseases (GSDs)[1].
| Name | yGsy2p-IN-H23 |
|---|
| Description | yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for glycogen storage diseases (GSDs)[1]. |
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| Related Catalog | |
| Target |
IC50: 875 µM (hGYS1)[1] |
| In Vitro | yGsy2p-IN-H23 (H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 of 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1]. |
| References |
| Molecular Formula | C23H27N3O2 |
|---|---|
| Molecular Weight | 377.48 |