yGsy2p-IN-H23
Modify Date: 2025-08-27 08:13:42
yGsy2p-IN-H23 structure
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Common Name | yGsy2p-IN-H23 | ||
|---|---|---|---|---|
| CAS Number | 1269190-98-8 | Molecular Weight | 377.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H27N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of yGsy2p-IN-H23yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for glycogen storage diseases (GSDs)[1]. |
| Name | yGsy2p-IN-H23 |
|---|
| Description | yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for glycogen storage diseases (GSDs)[1]. |
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| Related Catalog | |
| Target |
IC50: 875 µM (hGYS1)[1] |
| In Vitro | yGsy2p-IN-H23 (H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 of 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1]. |
| References |
| Molecular Formula | C23H27N3O2 |
|---|---|
| Molecular Weight | 377.48 |
| InChIKey | YGPHAIXUDLLWHC-UHFFFAOYSA-N |
| SMILES | COc1cc(-c2c(-c3ccccc3)ncn2CCC2CCCN2C)ccc1O |