1401436-95-0

1401436-95-0 structure

Name: Zandelisib
Chemical Name: Zandelisib
CAS Number: 1401436-95-0
Molecular Formula: C₃₁H₃₈F₂N₈O
Molecular Weight: 576.68
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2020-06-01 18:26:30
Modify Date: 2024-01-03 22:17:05
Zandelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic[1][2].

Name	Zandelisib

Description	Zandelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kδ:3.5 nM (IC50)
In Vitro	Zandelisib inhibits PI3Ks with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM for p110α, p110β, p110γ and p110δ, respectivey[1].
References	[1]. Daniel P. Gold, et al. Combination therapy. WO2019183226A1. [2]. David Brown, et al. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases. WO2014055647A1.

Hazard Codes	Xn