1611990-01-2

1611990-01-2 structure

Name: Aeruginosin 865
Chemical Name: Aeruginosin 865
CAS Number: 1611990-01-2
Molecular Formula: C₄₁H₆₄N₆O₁₄
Molecular Weight: 864.98
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2020-08-07 18:48:45
Modify Date: 2024-01-02 12:57:11
Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect[1]

Name	Aeruginosin 865

Description	Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect[1]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Research Areas >> Inflammation/Immunology
In Vitro	Aeruginosin 865 (pretreatment with 0.1-100 μg/mL) shows significant inhibition of IL-8 (EC50=3.5 μg/mL) and ICAM-1 (EC50=50.0 μg/mL) in hTNF-α-stimulated HLMVECs in a concentration-dependent manner. Aeruginosin 865 does not affect cell viability, even at much higher concentration in HeLa, HepG2 cells[1]. Aeruginosin 865 (100-200 μM) shows high-dose cytotoxicity in Mouse fibrosarcoma cells and with no cytotoxic effect in NIH/3T3 cells[2]. .
References	[1]. Aleksandra Kapuścik, et al. Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chembiochem. 2013 Nov 25;14(17):2329-37. [2]. Ivana Veselá, et al. Cytotoxic Effect of Aeruginosin-865, Resveratrol and Capsaicin on Mouse Fibroblasts and Cells Derived from Fallow Deer. Natural Product Communications, Volume: 13 issue: 2.

Molecular Formula	C₄₁H₆₄N₆O₁₄
Molecular Weight	864.98