1253226-93-5
1253226-93-5 structure
- Name: AS1708727
- Chemical Name: AS1708727
- CAS Number: 1253226-93-5
- Molecular Formula: C24H24Cl2N2O2
- Molecular Weight: 443.37
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-08-10 20:51:26
- Modify Date: 2025-08-25 06:41:55
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AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively[1].
| Name | AS1708727 |
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| Description | AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively[1]. |
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| Related Catalog | |
| In Vitro | AS1708727 suppresses increases in blood glucose level by inhibiting gluconeogenic gene expression[1]. RT-PCR[1] Cell Line: Fao cells, derived from the H4IIE hepatoma cell line. Concentration: 0.1-3000 μM. Incubation Time: 18 h. Result: Showed dose-dependent reduction in mRNA levels for G6Pase and PEPCK. |
| In Vivo | AS1708727 (30 to 300 mg/kg, orally) reduces both blood glucose and triglyceride levels, exhibiting anti-diabetic effects[1]. Animal Model: db/db mice aged six weeks[1]. Dosage: 100-1000 mg/kg (Pharmacokinetic Analysis). Administration: Orally. Result: Cmax) was 26.7 μM and maximum drug concentration time (Tmax) of 0.5 h at 300 mg/kg[1]. Liver concentration of AS1708727 at 0.5-2 h after oral administration was 3.7- to 5.4-fold higher than the plasma concentration, indicating good liver transition of AS1708727[1]. Animal Model: Diabetic model mice[1]. Dosage: 30 to 300 mg/kg. Administration: Orally twice daily for 4 days. Result: Blood glucose level was significantly reduced at 300 mg/kg[1]. Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly reduced at 300 mg/kg[1]. G6Pase and PEPCK mRNA levels were significantly reduced at dosages of 100 and 300 mg/kg[1]. |
| References |
| Molecular Formula | C24H24Cl2N2O2 |
|---|---|
| Molecular Weight | 443.37 |