Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CEM114
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2279062-54-1

2279062-54-1 structure

2279062-54-1 structure

Name: CEM114
Chemical Name: CEM114
CAS Number: 2279062-54-1
Molecular Formula: C₈₄H₁₂₂FN₉O₁₉S
Molecular Weight: 1612.98
Catalog: Signaling Pathways Cell Cycle/DNA Damage CRISPR/Cas9
Create Date: 2020-08-08 09:23:06
Modify Date: 2025-09-11 12:05:19
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

Name	CEM114

Description	CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CRISPR/Cas9 Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
In Vitro	CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1]. Cell Viability Assay[1] Cell Line: HEK 293T cells Concentration: 200 nM Incubation Time: 48 hours Result: Significantly activated the GFP signal.
References	[1]. Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.

Molecular Formula	C₈₄H₁₂₂FN₉O₁₉S
Molecular Weight	1612.98

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.