2279062-54-1

2279062-54-1 structure

2279062-54-1 structure

Name: CEM114
Chemical Name: CEM114
CAS Number: 2279062-54-1
Molecular Formula: C₈₄H₁₂₂FN₉O₁₉S
Molecular Weight: 1612.98
Catalog: Signaling Pathways Cell Cycle/DNA Damage CRISPR/Cas9
Create Date: 2020-08-08 09:23:06
Modify Date: 2024-01-16 13:34:58
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

Name	CEM114

Description	CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CRISPR/Cas9 Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
In Vitro	CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1]. Cell Viability Assay[1] Cell Line: HEK 293T cells Concentration: 200 nM Incubation Time: 48 hours Result: Significantly activated the GFP signal.
References	[1]. Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.

Molecular Formula	C₈₄H₁₂₂FN₉O₁₉S
Molecular Weight	1612.98