CEM114

Modify Date: 2025-09-11 12:05:19

CEM114 structure	Common Name	CEM114
	CAS Number	2279062-54-1	Molecular Weight	1612.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₄H₁₂₂FN₉O₁₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CEM114

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

Name	CEM114

Description	CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CRISPR/Cas9 Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
In Vitro	CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1]. Cell Viability Assay[1] Cell Line: HEK 293T cells Concentration: 200 nM Incubation Time: 48 hours Result: Significantly activated the GFP signal.
References	[1]. Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.

Molecular Formula	C₈₄H₁₂₂FN₉O₁₉S
Molecular Weight	1612.98
InChIKey	JPTHTRDMYPXUQU-GWBWRJFESA-N
SMILES	COC1CC(C=C(C)C2OC(=O)C3CCCCN3C(=O)C(=O)C3(O)OC(C(OC)CC(C)CC(C)=CC(CCCSCCC(=O)NCCOCCOCCOCCn4cc(COc5ccc(CCc6nc7cc(-c8c(C)noc8C)ccc7n6CCN6CCOCC6)cc5F)nn4)C(=O)CC(O)C2C)C(OC)CC3C)CCC1O

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