2055597-12-9
2055597-12-9 structure
- Name: ERK-IN-3
- Chemical Name: ERK-IN-3
- CAS Number: 2055597-12-9
- Molecular Formula: C22H25ClFN7O2
- Molecular Weight: 473.93
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2020-08-07 12:48:16
- Modify Date: 2024-01-01 18:26:18
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ERK-IN-3 is a potent and oral inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations.[1].
| Name | ERK-IN-3 |
|---|
| Description | ERK-IN-3 is a potent and oral inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations.[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK1 ERK2 |
| In Vitro | ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1]. ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. |
| In Vivo | ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1]. |
| References |
| Molecular Formula | C22H25ClFN7O2 |
|---|---|
| Molecular Weight | 473.93 |