1208862-61-6

1208862-61-6 structure

Name: H-Ile-Pro-Pro-OH hydrochloride
Chemical Name: H-Ile-Pro-Pro-OH hydrochloride
CAS Number: 1208862-61-6
Molecular Formula: C₁₆H₂₈ClN₃O₄
Molecular Weight: 361.86
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2020-08-07 18:32:17
Modify Date: 2024-01-17 12:20:19
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

Name	H-Ile-Pro-Pro-OH hydrochloride

Description	H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 5 μM (ACE)[2]
In Vitro	Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].
In Vivo	Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1] Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1]. Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].
References	[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

Molecular Formula	C₁₆H₂₈ClN₃O₄
Molecular Weight	361.86