H-Ile-Pro-Pro-OH hydrochloride

Modify Date: 2024-01-17 12:20:19

H-Ile-Pro-Pro-OH hydrochloride Structure
H-Ile-Pro-Pro-OH hydrochloride structure
Common Name H-Ile-Pro-Pro-OH hydrochloride
CAS Number 1208862-61-6 Molecular Weight 361.86
Density N/A Boiling Point N/A
Molecular Formula C16H28ClN3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-Ile-Pro-Pro-OH hydrochloride


H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

 Names

Name H-Ile-Pro-Pro-OH hydrochloride

 H-Ile-Pro-Pro-OH hydrochloride Biological Activity

Description H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].
Related Catalog
Target

IC50: 5 μM (ACE)[2]

In Vitro Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].
In Vivo Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1] Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1]. Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].
References

[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7.

[2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

 Chemical & Physical Properties

Molecular Formula C16H28ClN3O4
Molecular Weight 361.86
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