2102101-72-2

2102101-72-2 structure

Name: IPN60090 dihydrochloride
Chemical Name: IPN-60090 dihydrochloride
CAS Number: 2102101-72-2
Molecular Formula: C₂₄H₂₉Cl₂F₃N₈O₃
Molecular Weight: 605.44
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-08-11 09:15:33
Modify Date: 2025-08-27 15:11:50
IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].

Name	IPN-60090 dihydrochloride

Description	IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	GLS1[1]
In Vitro	IPN-60090 dihydrochloride (Example 1) has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM[2].
References	[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2. [2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.

Molecular Formula	C₂₄H₂₉Cl₂F₃N₈O₃
Molecular Weight	605.44