IPN60090 dihydrochloride

Modify Date: 2025-08-27 15:11:50

IPN60090 dihydrochloride Structure
IPN60090 dihydrochloride structure
Common Name IPN60090 dihydrochloride
CAS Number 2102101-72-2 Molecular Weight 605.44
Density N/A Boiling Point N/A
Molecular Formula C24H29Cl2F3N8O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IPN60090 dihydrochloride


IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].

 Names

Name IPN-60090 dihydrochloride

 IPN60090 dihydrochloride Biological Activity

Description IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].
Related Catalog
Target

GLS1[1]

In Vitro IPN-60090 dihydrochloride (Example 1) has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM[2].
References

[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2.

[2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.

 Chemical & Physical Properties

Molecular Formula C24H29Cl2F3N8O3
Molecular Weight 605.44
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