Name | NBD-125 |
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Description | NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1]. |
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Related Catalog | |
Target |
RXRα |
In Vitro | NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1]. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1]. Western Blot Analysis[1] Cell Line: Km12c, HCT116 and SW620 cell lines. Concentration: 0-50 μM, 0-60, 0-80 μM. Incubation Time: 15 h. Result: Downregulated c-Myc, Cdc42 protein levels. |
References |
Molecular Formula | C19H18ClNO2 |
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Molecular Weight | 327.80 |