2367641-24-3

2367641-24-3 structure
2367641-24-3 structure
  • Name: NBD-125
  • Chemical Name: NBD-125
  • CAS Number: 2367641-24-3
  • Molecular Formula: C19H18ClNO2
  • Molecular Weight: 327.80
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
  • Create Date: 2020-08-07 12:24:14
  • Modify Date: 2024-01-10 12:11:19
  • NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

Name NBD-125
Description NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].
Related Catalog
Target

RXRα

In Vitro NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1]. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1]. Western Blot Analysis[1] Cell Line: Km12c, HCT116 and SW620 cell lines. Concentration: 0-50 μM, 0-60, 0-80 μM. Incubation Time: 15 h. Result: Downregulated c-Myc, Cdc42 protein levels.
References

[1]. Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63(11):5841-5855.

Molecular Formula C19H18ClNO2
Molecular Weight 327.80