Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NBD-125
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2367641-24-3

2367641-24-3 structure

2367641-24-3 structure

Name: NBD-125
Chemical Name: NBD-125
CAS Number: 2367641-24-3
Molecular Formula: C₁₉H₁₈ClNO₂
Molecular Weight: 327.80
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2020-08-07 12:24:14
Modify Date: 2025-08-26 19:28:16
NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

Name	NBD-125

Description	NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXRα
In Vitro	NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1]. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1]. Western Blot Analysis[1] Cell Line: Km12c, HCT116 and SW620 cell lines. Concentration: 0-50 μM, 0-60, 0-80 μM. Incubation Time: 15 h. Result: Downregulated c-Myc, Cdc42 protein levels.
References	[1]. Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63(11):5841-5855.

Molecular Formula	C₁₉H₁₈ClNO₂
Molecular Weight	327.80

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