NBD-125

Modify Date: 2024-01-10 12:11:19

NBD-125 structure	Common Name	NBD-125
	CAS Number	2367641-24-3	Molecular Weight	327.80
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₈ClNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NBD-125

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

Name	NBD-125

Description	NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXRα
In Vitro	NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1]. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1]. Western Blot Analysis[1] Cell Line: Km12c, HCT116 and SW620 cell lines. Concentration: 0-50 μM, 0-60, 0-80 μM. Incubation Time: 15 h. Result: Downregulated c-Myc, Cdc42 protein levels.
References	[1]. Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63(11):5841-5855.

Molecular Formula	C₁₉H₁₈ClNO₂
Molecular Weight	327.80

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NBD-125
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