2413716-71-7

2413716-71-7 structure

Name: MPro Inhibitor 11b
Chemical Name: SARS-CoV MPro-IN-1
CAS Number: 2413716-71-7
Molecular Formula: C₂₅H₂₅FN₄O₄
Molecular Weight: 464.49
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2020-08-08 12:09:33
Modify Date: 2024-01-09 08:20:22
SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].

Name	SARS-CoV MPro-IN-1

Description	SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vivo	SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg[1].
References	[1]. Dai W, et al. Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. bioRxiv; 2020.

Molecular Formula	C₂₅H₂₅FN₄O₄
Molecular Weight	464.49