463356-00-5

463356-00-5 structure

Name: Sordarin sodium
Chemical Name: Sordarin sodium
CAS Number: 463356-00-5
Molecular Formula: C₂₇H₃₉NaO₈
Molecular Weight: 514.58
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2020-08-08 09:12:15
Modify Date: 2024-01-11 16:21:47
Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae)[1][2].

Name	Sordarin sodium

Description	Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae)[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
Target	IC50: eEF2; fungal[1]
References	[1]. Wael Abdel-Fattah, et al. Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel). 2013 May 3;5(5):958-68. [2]. Biprashekhar Chakraborty, et al. Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity. J Mol Graph Model. 2016 May;66:133-42.

Molecular Formula	C₂₇H₃₉NaO₈
Molecular Weight	514.58

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport