2365172-19-4
2365172-19-4 structure
- Name: XZ739
- Chemical Name: XZ739
- CAS Number: 2365172-19-4
- Molecular Formula: C65H76ClF3N8O12S3
- Molecular Weight: 1349.99
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-08-10 23:24:00
- Modify Date: 2024-01-10 22:12:29
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XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
| Name | XZ739 |
|---|
| Description | XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1]. |
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| Related Catalog | |
| Target |
Bcl-xL:2.5 nM (DC50) Cereblon |
| In Vitro | XZ739 (0.001-10 μM; 48 hours) potently reduces the viability of T-ALL MOLT-4, B-ALL RS4; 11, SCLC NCI-H146 cells, and platelets after 48 h treatment with IC50s of 10.1, 41.8, 25.3, and 1217 nM, respectively. XZ739 has >100-fold selectivity for MOLT-4 cells over human platelets[1]. XZ739 (1.2-300 nM; 16 hours) induces BCL-XL degradation in MOLT-4 cells[1]. The BCL-XL degradation induced by XZ739 in MOLT-4 is rapid, starting within 2 h; and 8 h after XZ739 treatment, more than 96% of the BCL-XL is degraded with 100 nM of XZ739[1]. Cell Viability Assay[1] Cell Line: Human platelets and MOLT-4 cells Concentration: 0.001, 0.01, 0.1, 1, and 10 μM Incubation Time: 48 hours Result: IC50 values were 10.1 nM and 1217 nM for MOLT-4 cells and platelets, respectively. Western Blot Analysis[1] Cell Line: MOLT-4 cells Concentration: 1.2, 3.7, 11, 33, 100, 300 nM Incubation Time: 16 hours Result: Dose-dependently induced BCL-XL degradation. |
| References |
| Molecular Formula | C65H76ClF3N8O12S3 |
|---|---|
| Molecular Weight | 1349.99 |
| Hazard Codes | Xi |
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