129425-81-6
129425-81-6 structure
- Name: MSA 2
- Chemical Name: MSA-2
- CAS Number: 129425-81-6
- Molecular Formula: C14H14O5S
- Molecular Weight: 294.32
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2020-09-12 14:34:04
- Modify Date: 2024-01-02 18:14:34
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MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1].
| Name | MSA-2 |
|---|---|
| Synonyms | 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid |
| Description | MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1]. |
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| Related Catalog | |
| In Vivo | MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals[1]. MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor[1]. Animal Model: MC38 tumor-bearing C57BL6 mice[1] Dosage: 60 mg/kg Administration: P.o. ; s.c (50 mg/kg); single dose Result: PO or SC doses of MSA-2 that effectively inhibited tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor. |
| References |
| Molecular Formula | C14H14O5S |
|---|---|
| Molecular Weight | 294.32 |
| Storage condition | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |