1926163-30-5
1926163-30-5 structure
- Name: Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt
- Chemical Name: Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt
- CAS Number: 1926163-30-5
- Molecular Formula: C94H174N32O22S2
- Molecular Weight: 2168.75
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2021-01-10 13:07:31
- Modify Date: 2024-04-02 18:15:24
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Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1].
| Name | Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt |
|---|
| Description | Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1]. |
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| Related Catalog | |
| In Vitro | Tumor targeted pro-apoptotic peptide (10 µM; 0-20 min) induces mitochondrial swelling in DMECs[1]. Tumor targeted pro-apoptotic peptide (100 µM; 72 h) induces apoptosis in DMECs[1]. Cell Viability Assay[1] Cell Line: DMECs Concentration: 10 µM Incubation Time: 0-20 min Result: Induced considerable mitochondrial swelling at a concentration of 10 µM, and mild swelling was evident even at 3 µM. Apoptosis Analysis[1] Cell Line: DMECs Concentration: 100 µM Incubation Time: 72 h Result: Showed the classic morphological indicators of apoptosis, including nuclear condensation and fragmentation. |
| In Vivo | Tumor targeted pro-apoptotic peptide inhibits both primary tumor growth and metastasis in mice[1]. Animal Model: Tumor targeted pro-apoptotic peptide (250 µg/mice; tail vein injection; 250 µg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1]. Dosage: 250 µg/mice Administration: Tail vein injection; 250 µg a week for 17 weeks Result: Exhibited antitumor activity in vivo. |
| Molecular Formula | C94H174N32O22S2 |
|---|---|
| Molecular Weight | 2168.75 |