1926163-30-5

1926163-30-5 structure

Name: Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt
Chemical Name: Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt
CAS Number: 1926163-30-5
Molecular Formula: C₉₄H₁₇₄N₃₂O₂₂S₂
Molecular Weight: 2168.75
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-01-10 13:07:31
Modify Date: 2024-04-02 18:15:24
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1].

Name	Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt

Description	Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Tumor targeted pro-apoptotic peptide (10 µM; 0-20 min) induces mitochondrial swelling in DMECs[1]. Tumor targeted pro-apoptotic peptide (100 µM; 72 h) induces apoptosis in DMECs[1]. Cell Viability Assay[1] Cell Line: DMECs Concentration: 10 µM Incubation Time: 0-20 min Result: Induced considerable mitochondrial swelling at a concentration of 10 µM, and mild swelling was evident even at 3 µM. Apoptosis Analysis[1] Cell Line: DMECs Concentration: 100 µM Incubation Time: 72 h Result: Showed the classic morphological indicators of apoptosis, including nuclear condensation and fragmentation.
In Vivo	Tumor targeted pro-apoptotic peptide inhibits both primary tumor growth and metastasis in mice[1]. Animal Model: Tumor targeted pro-apoptotic peptide (250 µg/mice; tail vein injection; 250 µg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1]. Dosage: 250 µg/mice Administration: Tail vein injection; 250 µg a week for 17 weeks Result: Exhibited antitumor activity in vivo.

Molecular Formula	C₉₄H₁₇₄N₃₂O₂₂S₂
Molecular Weight	2168.75