196109-27-0
196109-27-0 structure
- Name: Exendin (5-39)
- Chemical Name: Exendin (5-39)
- CAS Number: 196109-27-0
- Molecular Formula: C169H262N44O54S
- Molecular Weight: 3806.30
- Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
- Create Date: 2020-10-18 16:20:05
- Modify Date: 2024-01-03 16:01:57
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Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1].
| Name | Exendin (5-39) |
|---|
| Description | Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1]. |
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| Related Catalog | |
| Target |
IC50: GLP-1 receptor[1] |
| In Vivo | Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1]. Animal Model: Wistar rats (3 weeks old and 18 days pregnant)[1] Dosage: 0.3 μg Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats. |
| References |
| Molecular Formula | C169H262N44O54S |
|---|---|
| Molecular Weight | 3806.30 |