1374639-74-3
1374639-74-3 structure
- Name: Gemigliptin tartrate
- Chemical Name: Gemigliptin tartrate
- CAS Number: 1374639-74-3
- Molecular Formula: C22H25F8N5O8
- Molecular Weight: 639.45
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Dipeptidyl Peptidase
- Create Date: 2020-11-28 13:55:31
- Modify Date: 2024-01-08 09:38:36
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Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications[1][2].
| Name | Gemigliptin tartrate |
|---|
| Description | Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications[1][2]. |
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| Related Catalog | |
| Target |
IC50: 10.3 nM (human recombinant DPP-4)[2] |
| In Vitro | Gemigliptin tartrate dose-dependently inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin tartrate dose-dependently suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM[2]. |
| In Vivo | Gemigliptin tartrate (100 mg/kg; i.g.; daily; for 12 weeks) inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2]. Animal Model: Male C57BL/KsJ-db/db mice (7 weeks old)[1] Dosage: 100 mg/kg Administration: Oral gavage, daily, for 12 weeks Result: Significantly reduced circulating AGE levels by 44.5% in serum. |
| References |
| Molecular Formula | C22H25F8N5O8 |
|---|---|
| Molecular Weight | 639.45 |